Referencias Bibliográficas sobre Psiquiatría Biológica:
A Sawa, SH
Snyder: Schizophrenia: diverse approaches to a complex disease.
Science 2002, 296: 692-695
IIGottesman: Schizophrenia Genesis: The Origins of Madness. New York: W.H. Freeman; 1991
HW Moises,
II Gottesman: Genetics, risk and personality factors.
In: Contemporary Psychiatry (Edited by: Henn F, Sartorius, H, Helmchen H, Lauter,
N). Heidelberg, New York: Springer 2000, 3: 47-59
II Gottesman: Psychopathology through a life span – genetic prism.
Am Psychologist 2001, 56: 867-878
RM Murray,
SW Lewis: Is schizophrenia a neurodevelopmental disorder?
Br Med J 1987, 295: 681-682
S Marenco,
DR Weinberger: The neurodevelopmental hypothesis of schizophrenia: following a
trail of evidence from cradle to grave.
Dev Psychopathol 2000, 12: 501-527
HWM Moises:
Human Genome data analyzed by an evolutionary method suggests a decrease in
protein-synthesis rate as cause of schizophrenia and an increase as
antipsychotic mechanism.
ArXiv.org e-Print archive 2001
DA Lewis, P
Levitt: Schizophrenia as a disorder of neurodevelopment.
Annu Rev Neurosci 2002, 25: 409-432
CS Monk, SJ
Webb, CA Nelson: Prenatal neurobiological development: molecular mechanisms and
anatomical change.
Dev Neuropsychol 2001, 19: 211-236
SJ Webb, CS
Monk, CA Nelson: Mechanisms of postnatal neurobiological development:
implications for human development.
Dev Neuropsychol 2001, 19: 147-171
G Lemke:
Glial control of neuronal development.
Annu Rev Neurosci 2001, 24: 87-105
DR Cotter,
CM Pariante, IP Everall: Glial abnormalities in major psychiatric disorders: the
evidence and implications.
Brain Res Bull 2001, 55: 585-595
Y Hakak, JR
Walker, C Li, WH Wong, KL Davis, JD Buxbaum, V Haroutunian, AA Fienberg:
Genome-wide expression analysis reveals dysregulation of myelination-related
genes in chronic schizophrenia.
Proc Natl Acad Sci U S A 2001, 98: 4746-4751
M
Rothermundt, U Missler, V Arolt, M Peters, J Leadbeater, M Wiesmann, S Rudolf,
KP Wandinger, H Kirchner: Increased S100B blood levels in unmedicated and
treated schizophrenic patients are correlated with negative symptomatology.
Mol Psychiatry 2001, 6: 445-449
DR Lara, CS
Gama, P-de-Abreu Belmonte, LV Portela, CA Goncalves, M Fonseca, S Hauck, DO
Souza: Increased serum S100B protein in schizophrenia: a study in
medication-free patients.
J Psychiatr Res 2001, 35: 11-14
NM Williams,
MC O'Donovan, MJ Owen: Genome scans and microarrays: converging on genes for
schizophrenia?
Genome Biology 2002 2002, 3: 1-1011
AB Goodman:
Three independent lines of evidence suggest retinoids as causal to
schizophrenia.
Proc Natl Acad Sci U S A 1998, 95: 7240-7244
ABr
Niculescu, JR Kelsoe: Convergent functional genomics: application to bipolar
disorder.
Ann Med 2001, 33: 263-271
K Mirnics,
FA Middleton, GD Stanwood, DA Lewis, P Levitt: Disease-specific changes in
regulator of G-protein signaling 4 (RGS4) expression in schizophrenia.
Mol Psychiatry 2001, 6: 293-301
S Burden, Y
Yarden: Neuregulins and their receptors: a versatile signaling module in
organogenesis and oncogenesis.
Neuron 1997, 18: 847-855
A Buonanno,
GD Fischbach: Neuregulin and ErbB receptor signaling pathways in the nervous
system.
Curr Opin Neurobiol 2001, 11: 287-296
H Song, CF
Stevens, FH Gage: Astroglia induce neurogenesis from adult neural stem cells.
Nature 2002, 417: 425
PG Haydon:
GLIA: listening and talking to the synapse.
Nat Rev Neurosci 2001, 2: 185-193
A Araque, V
Parpura, RP Sanzgiri, PG Haydon: Tripartite synapses: glia, the unacknowledged
partner.
Trends Neurosci 1999, 22: 208-215
SJ Morley:
Signal transduction mechanisms in the regulation of protein synthesis.
Mol Biol Rep 1994, 19: 221-231
O Steward,
EM Schuman: Protein synthesis at synaptic sites on dendrites.
Annu Rev Neurosci 2001, 24: 299-325
EM Schuman:
Neurotrophin regulation of synaptic transmission.
Curr Opin Neurobiol 1999, 9: 105-109
L Fromm, SJ
Burden: Neuregulin-1-stimulated phosphorylation of GABP in skeletal muscle
cells.
Biochemistry 2001, 40: 5306-5312
P Bezzi, A
Volterra: A neuron-glia signalling network in the active brain.
Curr Opin Neurobiol 2001, 11: 387-394
YZ Huang, S
Won, DW Ali, Q Wang, M Tanowitz, QS Du, KA Pelkey, DJ Yang, WC Xiong, MW Salter,
L Mei: Regulation of neuregulin signaling by PSD-95 interacting with erbB4 and
CNS synapses.
Neuron 2000, 26: 443-455
ES Anton, MA
Marchionni, KF Lee, P Rakic: Role of GGF/neuregulin signaling in interactions
between migrating neurons and radial glia in the developing cerebral cortex.
Development 1997, 124: 3501-3510
V Calaora, B
Rogister, K Bismuth, K Murray, H Brandt, P Leprince, M Marchionni, M Dubois-Dalcq:
Neuregulin signaling regulates neural precursor growth and the generation of
oligodendrocytes in vitro.
J Neurosci 2001, 21: 4740-4751
D Wolpowitz,
TB Mason, P Dietrich, M Mendelsohn, DA Talmage, LW Role: Cysteine-rich domaine
isoforms of the neuregulin-1 gene are required for maintenance of periphereal
synapses.
Neuron 2000, 25: 79-91
JA Loeb, A
Hmadcha, GD Fischbach, SJ Land, VL Zakarian: Neuregulin expression at
neuromuscular synapses is modulated by synaptic activity and neurotrophic
factors.
J Neurosci 2002, 22: 2206-
K Adlkofer,
C Lai: Role of neuregulins in glial cell development.
Glia 2000, 29: 104-107
JY Wang, KE
Frenzel, D Wen, DL Falls: Transmembrane neuregulins interact with LIM kinase 1,
a cytoplasmic protein kinase implicated in development of visuospatial
cognition.
J Biol Chem 1998, 273: 20525-20534
MA Olayioye,
RM Neve, HA Lane, NE Hynes: The ErbB signaling network: receptor
heterodimerization in development and cancer.
EMBO J 2000, 19: 3159-3167
Y Liu, B
Ford, MA Mann, GD Fischbach: Neuregulins increase alpha7 nicotinic acetylcholine
receptors and enhance excitatory synaptic transmission in GABAergic interneurons
of the hippocampus.
J Neuroci 2001, 21: 5660-5669
MK Sapru, SK
Florance, C Kirk, D Goldman: Identification of a neuregulin and protein-tyrosine
phosphatase response element in the nicotinic acetylcholine receptor E subunit
gene: Regulatory role of an Ets transcription factor.
Proc Natl Acad Sci U S A 1998, 95: 1289-1294
DE Syroid,
TS Zorick, C Arbet-Engels, TJ Kilpatrick, W Eckhart, G Lemke: A role for
insulin-like growth factor-I in the regulation of Schwann cell survival.
J Neurosci 1999, 19: 2059-2068
CM Hertig,
SW Kubalak, Y Wang, KR Chien: Synergistic roles of neuregulin-1 and insulin-like
growth factor-I in activation of the phosphatidylinositol 3-kinase pathway and
cardiac chamber morphogenesis.
J Biol Chem 1999, 274: 37362-37369
C Sweeney, D
Fambrough, C Huard, AJ Diamonti, ES Lander, LC Cantley, KL Carraway 3rd: Growth
factor-specific signaling pathway stimulation and gene expression mediated by
ErbB receptors.
J Biol Chem 2001, 276: 22685-22698
LA Scheving,
WE Russell: Insulin and heregulin-beta1 upregulate guanylyl cyclase C expression
in rat hepatocytes: reversal by phosphodiesterase-3 inhibition.
Cell Signal 2001, 13: 665-672
R Li, J
Chen, G Hammonds, H Phillips, M Armanini, P Wood, R Bunge, PJ Godowski, MX
Sliwkowski, JP Mather: Identification of Gas6 as a growth factor for human
Schwann cells.
J Neurosci 1996, 16: 2012-2019
MP Allen, C
Zeng, K Schneider, X Xiong, MK Meintzer, P Bellosta, C Basilico, B Varnum, KA
Heidenreich, ME Wierman: Growth arrest-specific gene 6 (Gas6)/adhesion related
kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival
via extracellular signal-regulated kinase (ERK) and Akt.
Mol Endocrinol 1999, 13: 191-201
S Goruppi, E
Ruaro, B Varnum, C Schneider: Requirement of phosphatidylinositol
3-kinase-dependent pathway and Src for Gas6-Axl mitogenic and survival
activities in NIH 3T3 fibroblasts.
Mol Cell Biol 1997, 17: 4442-4453
R Eilam, R
Pinkas-Kramarski, BJ Ratzkin, M Segal, Y. Yarden: Activity-dependent regulation
of Neu differentiation factor/neuregulin expression in rat brain.
Proc Natl Acad Sci U S A 1998, 95: 1888-1893
GS Naeve, M
Ramakrishnan, R Kramer, D Hevroni, Y Citri, LE Theill: Neuritin: a gene induced
by neural activity and neurotrophins that promotes neuritogenesis.
Proc Natl Acad Sci U S A 1997, 94: 2648-2653
P Subramony,
SE Dryer: Neuregulins stimulate the functional expression of Ca2+-activated K+
channels in developing chicken parasympathetic neurons.
Proc Natl Acad Sci U S A 1997, 94: 5934-5938
JS Cameron,
L Dryer, SE Dryer: beta-Neuregulin-1 is required for the in vivo development of
functional Ca2+-activated K+ channels in parasympathetic neurons.
Proc Natl Acad Sci U S A 2001, 98: 2832-2836
H Thoenen:
Neurotrophins and neuronal plasticity.
Science 1995, 270: 593-598
M Canossa, O
Griesbeck, B Berninger, G Campana, R Kolbeck, H Thoenen: Neurotrophin release by
neurotrophins: implications for activity-dependent neuronal plasticity.
Proc Natl Acad Sci U S A 1997, 94: 13279-13286
U Otten, P
Marz, K Heese, C Hock, D Kunz, S Rose-John: Cytokines and neurotrophins interact
in normal and diseased states.
Ann N Y Acad Sci 2000, 917: 322-330
M
Canossa, A Gartner, G Campana, N Inagaki, H Thoenen: Regulated secretion of
neurotrophins by metabotropic glutamate group I (mGluRI) and Trk receptor
activation is mediated via phospholipase C signalling pathways.
Embo J 2001, 20: 1640-1650
E Alleva,
D Santucci: Psychosocial vs.
"physical" stress situations in rodents and humans: role of neurotrophins.
Physiol Behav 2001, 73: 313-320
RR Baliga,
DR Pimental, YY Zhao, WW Simmons, MA Marchionni, DB Sawyer, RA Kelly:
NRG-1-induced cardiomyocyte hypertrophy. Role of PI-3-kinase, p70(S6K), and
MEK-MAPK-RSK.
Am J Physiol 1999, 277: H2026-2037
M Kleijn, GI
Welsh, GC Scheper, HO Voorma, CG Proud, AA Thomas: Nerve and epidermal growth
factor induce protein synthesis and eIF2B activation in PC12 cells.
J Biol Chem 1998, 273: 5536-5541
DG Wells, JD
Richter, JR Fallon: Molecular mechanisms for activity-regulated protein
synthesis in the synapto-dendritic compartment.
Curr Opin Neurobiol 2000, 10: 132-137
ER
Kandel, JH Schwartz, TM Jessell:
Essentials of Neural Science and Behavior. London: Prentice Hall; 1995
M Shelly, R
Pinkas-Kramarski, BC Guarino, H Waterman, LM Wang, L Lyass, M Alimandi, A Kuo,
SS Bacus, JH Pierce, GC Andrews, Y Yarden: Epiregulin is a potent pan-ErbB
ligand that preferentially activates heterodimeric receptor complexes.
J Biol Chem 1998, 273: 10496-10505
R Gerlai, N
Shinsky, A Shih, P Williams, J Winer, M Armanini, B Cairns, J Winslow, W Gao, HS
Phillips: Regulation of learning by EphA receptors: a protein targeting study.
J Neurosci 1999, 19: 9538-9549
JC Conover,
F Doetsch, JM Garcia-Verdugo, NW Gale, GD Yancopoulos, A Alvarez-Buylla:
Disruption of Eph/ephrin signaling affects migration and proliferation in the
adult subventricular zone.
Nat Neurosci 2000, 3: 1091-1097
JP Wagner,
IB Black, E DiCicco-Bloom: Stimulation of neonatal and adult brain neurogenesis
by subcutaneous injection of basic fibroblast growth factor.
J Neurosci 1999, 19: 6006-6016
AL Boxer, H
Moreno, B Rudy, EB Ziff: FGF-2 potentiates Ca(2+)-dependent inactivation of NMDA
receptor currents in hippocampal neurons.
J Neurophysiol 1999, 82: 3367-3377
DM Araujo,
CW Cotman: Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal
cultures: potential involvement of glial-derived factors.
Brain Res 1993, 600: 49-55
EC Beattie,
D Stellwagen, W Morishita, JC Bresnahan, BK Ha, M Von Zastrow, MS Beattie, RC
Malenka: Control of synaptic strength by glial TNFalpha.
Science 2002, 295: 2282-2285
R Hemi, K
Paz, N Wertheim, A Karasik, Y Zick, H Kanety: Transactivation of ErbB2 and ErbB3
by tumor necrosis factor-alpha and anisomycin leads to impaired insulin
signaling through serine/threonine phosphorylation of IRS proteins.
J Biol Chem 2002, 277: 8961-8969
A Carrie, L
Jun, T Bienvenu, MC Vinet, N McDonell, P Couvert, R Zemni, A Cardona, G Van
Buggenhout, S Frints, et al: A new member of the IL-1 receptor family highly
expressed in hippocampus and involved in X-linked mental retardation.
Nat Genet 1999, 23: 25-31
JH Pak, FL
Huang, J Li, D Balschun, KG Reymann, C Chiang, H Westphal, KP Huang: Involvement
of neurogranin in the modulation of calcium/calmodulin-dependent protein kinase
II, synaptic plasticity, and spatial learning: a study with knockout mice.
Proc Natl Acad Sci U S A 2000, 97: 11232-11237
H Häfner:
Onset and early course as determinants of the further course of schizophrenia.
Acta Psychiatr Scand Suppl 2000, 102: 44-48
J
Klosterkötter, M Hellmich, EM Steinmeyer, F Schultze-Lutter: Diagnosing
schizophrenia in the initial prodromal phase.
Arch Gen Psychiatry 2001, 58: 158-164
WIBBeveridge:
The art of scientific investigation. London: Mercury; 1965
S Leonard, J
Gault, T Moore, J Hopkins, M Robinson, A Olincy, LE Adler, CR Cloninger, CA
Kaufmann, et al: Further investigation of a chromosome 15 locus in
schizophrenia: analysis of affected sibpairs from the NIMH Genetics Initiative.
Am J Med Genet 1998, 81: 308-312
R Freedman,
H Coon, M Myles-Worsley, A Orr-Urtreger, A Olincy, A Davis, M Polymeropoulos, J
Holik, J Hopkins, M Hoff, et al: Linkage of a neurophysiological deficit in
schizophrenia to a chromosome 15 locus.
Proc Natl Acad Sci U S A 1997, 94: 587-592
J Williams,
P McGuffin, M Nöthen, MJ Owen: Meta-analysis of association between the 5-HT2a
receptor T102C polymorphism and schizophrenia. EMASS Collaborative Group.
European Multicentre Association Study of Schizophrenia.
Lancet 1997, 349: 1221
N Iwata, N
Ozaki, D Goldman: Association of a 5-HT(5A) receptor polymorphism, Pro15Ser, to
schizophrenia.
Mol Psychiatry 2001, 6: 217-219
E Jonsson, S
Brene, XR Zhang, VL Nimgaonkar, A Tylec, M Schalling, G Sedvall: Schizophrenia
and neurotrophin-alleles.
Acta Psychiatr Scand 1997, 95: 414-419
RS Devon, S
Anderson, PW Teague, WJ Muir, V Murray, A Pelosi, DH Blackwood, DJ Porteous: The
genomic organisation of the metabotropic glutamate receptor subtype 5 gene, and
its association with schizophrenia.
Mol Psychiatry 2001, 6: 311-314
J Wei, GP
Hemmings: The NOTCH4 locus is associated with susceptibility to schizophrenia.
Nat Genet 2000, 25: 376-377
HW
Moises, P Matthiasson, T Zoega, G Jhala, L Yang, II Gottesman, T. Helgason:
Neuregulin 1 strongly implicated as susceptibility gene for schizophrenia by
allelic association study.
ArXiv.org e-Print archive 2002
V Dror, E
Shamir, S Ghanshani, R Kimhi, M Swartz, Y Barak, R Weizman, L Avivi, T
Litmanovitch, E Fantino, et al: hKCa3/KCNN3 potassium channel gene: association
of longer CAG repeats with schizophrenia in Israeli Ashkenazi Jews, expression
in human tissues and localization to chromosome 1q21.
Mol Psychiatry 1999, 4: 254-260
H Liu, SC
Heath, C Sobin, JL Roos, BL Galke, ML Blundell, M Lenane, B Robertson, EM
Wijsman, JL Rapoport, et al: Genetic variation at the 22q11 PRODH2/DGCR6 locus
presents an unusual pattern and increases susceptibility to schizophrenia.
Proc Natl Acad Sci U S A 2002, 99: 3717-3722
A
Chakravarti: A compelling genetic hypothesis for a complex disease: PRODH2/DGCR6
variation leads to schizophrenia susceptibility.
Proc Natl Acad Sci U S A 2002, 99: 4755-4756
KV Chowdari,
K Mirnics, P Semwal, J Wood, E Lawrence, T Bhatia, SN Deshpande, KT B, RE
Ferrell, FA Middleton, et al: Association and linkage analyses of RGS4
polymorphisms in schizophrenia.
Hum Mol Genet 2002, 11: 1373-1380
S Wang, BA
Barres: Up a notch: instructing gliogenesis.
Neuron 2000, 27: 197-200
R
Meller, PJ Harrison, JM Elliott, T Sharp: In vitro evidence that
5-hydroxytryptamine increases efflux of glial glutamate via 5-HT(2A) receptor
activation.
J Neurosci Res 2002, 67: 399-405
SG Thompson,
PT Wong, SF Leong, EG McGeer: Regional distribution in rat brain of
1-pyrroline-5-carboxylate dehydrogenase and its localization to specific glial
cells.
J Neurochem 1985, 45: 1791-1796
KM Druey, KJ
Blumer, VH Kang, JH Kehrl: Inhibition of G-protein-mediated MAP kinase
activation by a new mammalian gene family.
Nature 1996, 379: 742-746
C Rio, HI
Rieff, P Qi, TS Khurana, G Corfas: Neuregulin and erbB receptors play a critical
role in neuronal migration.
Neuron 1997, 19: 39-50
A Araque, G
Carmignoto, PG Haydon: Dynamic signaling between astrocytes and neurons.
Annu Rev Physiol 2001, 63: 795-813
R Freedman,
CE Adams, S Leonard: The alpha7-nicotinic acetylcholine receptor and the
pathology of hippocampal interneurons in schizophrenia.
J Chem Neuroanat 2000, 20: 299-306
K O'Donnell,
IC Harkes, L Dougherty, IP Wicks: Expression of receptor tyrosine kinase Ax1 and
its ligand Gas6 in rheumatoid arthritis: evidence for a novel endothelial cell
survival pathway.
Am J Pathol 1999, 154: 1171-1180
JR Florini,
DS Samuel, DZ Ewton, C Kirk, RM Sklar: Stimulation of myogenic differentiation
by a neuregulin Glial Growth Factor 2.
J Biol Chem 1996, 271: 12699-12702
VK Han: The
ontogeny of growth hormone, insulin-like growth factors and sex steroids:
molecular aspects.
Horm Res 1996, 45: 61-63
YS Nakamura,
Y Hakeda, N Takakura, T Kameda, I Hamaguchi, T Miyamoto, S Kakudo, T Nakano, M
Kumegawa, T Suda: Tyro 3 receptor tyrosine kinase and its ligan, Gas6, stimulate
the function of osteoclasts.
Stem Cells 1998, 16: 229-238
A Dupont, O
Moeller-Jensen: Incidence of cancer in patients diagnosed as schizophrenic in
Denmark.
In: Psychiatric case registers in public health (Edited by: ten Horn GH, Giel R,
Gulbinat W, Henderson JH). Amsterdam, Elsevier 1986, 229-239
M Saku, S
Tokudome, M Ikeda, S Kono, K Makimoto, H Uchimura, A Mukai, T Yoshimura:
Mortality in psychiatric patients, with a specific focus on cancer mortality
associated with schizophrenia.
Int J Epidemiol 1995, 24: 366-372
EF Torrey, J
Miller, R Rawlings, RH Yolken: Seasonality of births in schizophrenia and
bipolar disorder: a review of the literature.
Schizophr Res 1997, 28: 1-38
N
Giannoukakis, J Deal, J Paquette, A Kukuvitis, C Polychronakos: Polymorphic
functional imprinting of the human IGF2 gene among individuals, in blood cells,
is associated with H19 expression.
Biochem Biophys Res Commun 1996, 220: 1014-1019
H Sasaki, K
Ishihara, R Kato: Mechanisms of Igf2/H19 imprinting: DNA methylation, chromatin
and long-distance gene regulation.
J Biochem (Tokyo) 2000, 127: 711-715
W Reik , A
Surani , eds:
Genomic Imprinting: Frontiers in Molecular Biology. Oxford: Oxford University
Press; 1997
L
Magnaghi-Jaulin, S Ait-Si-Ali, A Harel-Bellan: Histone acetylation in signal
transduction by growth regulatory signals.
Semin Cell Dev Biol 1999, 10: 197-203
W Lin, HB
Sanchez, T Deerinck, JK Morris, M Ellisman, K-F Lee: Aberrant development of
motor axons and neuromuscular synapses in erbB2-deficient mice.
Proc Natl Acad Sci U S A 2000, 97: 1299-1304
JW Crayton,
HY Meltzer: Motor endplate alterations in schizophrenic patients.
Nature 1976, 264: 658-659
J-Stanton
Ross, HY Meltzer: Motor neuron branching patterns in psychotic patients.
Arch Gen Psychiatry 1981, 38: 1097-1103
DH Mathalon,
EV Sullivan, KO Lim, A Pfefferbaum: Progressive brain volume changes and the
clinical course of schizophrenia in men: a longitudinal magnetic resonance
imaging study.
Arch Gen Psychiatry 2001, 58: 148-517
H Thoenen:
Neurotrophins and activity-dependent plasticity.
Prog Brain Res 2000, 128: 183-191
C Frith, RJ
Dolan: The Role of Memory in the Delusions Associated with Schizophrenia.
In: Memory, Brain, and Belief (Edited by: Schacter DL, Scarry E). Cambridge, MA,
Harvard University Press 2000, 115-135
VL
Nimgaonkar: Reduced fertility in schizophrenia: here to stay?
Acta Psychiatr Scand 1998, 98: 348-353
M Avila, G
Thaker, H Adami: Genetic epidemiology and schizophrenia: a study of reproductive
fitness.
Schizophr Res 2001, 47: 233-241
S Jones:
Natural selection in humans.
In: The Cambridge Encyclopedia of Human Evolution (Edited by: Jones S, Martin,
R, Pilbeam, D). Cambridge, Cambridge University Press 1992, 284-287
LF
Kastrukoff, SU Kim: Oligodendrocytes from human donors differ in resistance to
herpes simplex virus 1 (HSV-1).
Glia 2002, 38: 87-92
M Dubois-Dalcq:
Viral infections of neuroglial cells.
In: Neuroglia (Edited by: Kettenmann H, Ransom BR). New York, Oxford, Oxford
University Press , 1010-1026
B
Schweighardt, WJ Atwood: Glial cells as targets of viral infection in the human
central nervous system.
Prog Brain Res 2001, 132: 721-735]
AV Albright,
E Lavi, JB Black, S Goldberg, MJ O'Connor, F Gonzalez-Scarano: The effect of
human herpesvirus-6 (HHV-6) on cultured human neural cells: oligodendrocytes and
microglia.
J Neurovirol 1998, 4: 486-494
JE Friedman,
MJ Lyons, G Cu, DV Ablashl, JE Whitman, M Edgar, M Koskiniemi, A Vaheri, JB
Zabriskie: The association of the human herpesvirus-6 and MS.
Mult Scler 1999, 5: 355-362
PB Challoner,
KT Smith, JD Parker, DL MacLeod, SN Coulter, TM Rose, ER Schultz, JL Bennett, RL
Garber, M Chang, et al: Plaque-associated expression of human herpesvirus 6 in
multiple sclerosis.
Proc Natl Acad Sci U S A 1995, 92: 7440-7444
DA Clark:
Human herpesvirus 6.
Rev Med Virol 2000, 10: 155-173
S Bofill-Mas,
M Formiga-Cruz, P Clemente-Casares, F Calafell, R Girones: Potential
transmission of human polyomaviruses through the gastrointestinal tract after
exposure to virions or viral DNA.
J Virol 2001, 75: 10290-10299
EO Major, DA
Vacante: Human fetal astrocytes in culture support the growth of the neurotropic
human polyomavirus, JCV.
J Neuropathol Exp Neurol 1989, 48: 425-436
J Gordon, K
Khalili: The human polyomavirus, JCV, and neurological diseases (review).
Int J Mol Med 1998, 1: 647-655
A
Tretiakova, B Krynska, J Gordon, K Khalili: Human neurotropic JC virus early
protein deregulates glial cell cycle pathway and impairs cell differentiation.
J Neurosci Res 1999, 55: 588-599
S Bofill-Mas,
S Pina, R Girones: Documenting the epidemiologic patterns of polyomaviruses in
human populations by studying their presence in urban sewage.
Appl Environ Microbiol 2000, 66: 238-245
KM Weiss, JD
Terwilliger: How many diseases does it take to map a gene with SNPs?
Nat Genet 2000, 26: 151-157
JR Kidd, AJ
Pakstis, H Zhao, RB Lu, FE Okonofua, A Odunsi, E Grigorenko, BB Tamir, J
Friedlaender, LO Schulz, J Parnas, KK Kidd: Haplotypes and linkage
disequilibrium at the phenylalanine hydroxylase locus, PAH, in a global
representation of populations.
Am J Hum Genet 2000, 66: 1882-1899
D Wang, F
Sun: Sample sizes for the transmission disequilibrium tests: TDT, S-TDT and
1-TDT.
Commun Stat-Theory M 2000, 29: 1129-1142
AD Long, CH
Langley: The power of association studies to detect the contribution of
candidate genetic loci to variation in complex traits.
Genome Res 1999, 9: 720-731
LB Jorde:
Linkage disequilibrium and the search for complex disease genes.
Genome Res 2000, 10: 1435-1444
DF Levinson,
PA Holmans, C Laurent, B Riley, AE Pulver, PV Gejman, SG Schwab, NM Williams, MJ
Owen, DB Wildenauer, et al: No major schizophrenia locus detected on chromosome
1q in a large multicenter sample.
Science 2002, 296: 739-741]
JA Badner,
ES Gershon: Meta-analysis of whole-genome linkage scans of bipolar disorder and
schizophrenia.
Mol Psychiatry 2002, 7: 405-411
J Altmüller,
LJ Palmer, G Fischer, H Scherb, M Wjst: Genomewide scans of complex human
diseases: true linkage is hard to find.
Am J Hum Genet 2001, 69: 936-950
NJ Risch:
Searching for genetic determinants in the new millennium.
Nature 2000, 405: 847-856
M Wudarsky,
R Nicolson, SD Hamburger, L Spechler, P Gochman, J Bedwell, MC Lenane, JL
Rapoport: Elevated prolactin in pediatric patients on typical and atypical
antipsychotics.
J Child Adolesc Psychopharmacol 1999, 9: 239-245
RG Petty:
Prolactin and antipsychotic medications: mechanism of action.
Schizophr Res 1999, 35 Suppl: S67-73
H Wetzel, J
Wiesner, C Hiemke, O Benkert: Acute antagonism of dopamine D2-like receptors by
amisulpride: effects on hormone secretion in healthy volunteers.
J Psychiatr Res 1994, 28: 461-473
G Grunder, H
Wetzel, R Schlosser, I Anghelescu, A Hillert, K Lange, C Hiemke, O Benkert:
Neuroendocrine response to antipsychotics: effects of drug type and gender.
Biol Psychiatry 1999, 45: 89-97
CJ Bench, AA
Lammertsma, PM Grasby, RJ Dolan, SJ Warrington, M Boyce, KP Gunn, LY Brannick,
RS Frackowiak: The time course of binding to striatal dopamine D2 receptors by
the neuroleptic ziprasidone (CP-88,059-01) determined by positron emission
tomography.
Psychopharmacology (Berl) 1996, 124: 141-147
K Otani, T
Kondo, S Kaneko, M Ishida, Y Fukushima: Correlation between prolactin response
and therapeutic effects of zotepine in schizophrenic patients.
Int Clin Psychopharmacol 1994, 9: 287-289
KM Yazici, T
Erbas, AH Yazici: The effect of clozapine on glucose metabolism.
Exp Clin Endocrinol Diabetes 1998, 106: 475-477
KI
Melkersson, AL Hulting, KE Brismar: Different influences of classical
antipsychotics and clozapine on glucose-insulin homeostasis in patients with
schizophrenia or related psychoses.
J Clin Psychiatry 1999, 60: 783-791
KI
Melkersson, AL Hulting: Insulin and leptin levels in patients with schizophrenia
or related psychoses – a comparison between different antipsychotic agents.
Psychopharmacology (Berl) 2001, 154: 205-212
A Petronis,
II Gottesman, TJ Crow, LE DeLisi, AJ Klar, F Macciardi, MG McInnis, FJ McMahon,
AD Paterson, D Skuse, GR Sutherland: Psychiatric epigenetics: a new focus for
the new century.
Mol Psychiatry 2000, 5: 342-346
EF Torrey,
MR Peterson: Slow and latent viruses in schizophrenia.
Lancet 1973, 2: 22-24
JS Kim, HH
Kornhuber, W Schmid-Burgk, B Holzmüller: Low cerebrospinal fluid glutamate in
schizophrenic patients and a new hypothesis on schizophrenia.
Neurosci Lett 1980, 20: 379-382
JW Olney, JW
Newcomer, NB Farber: NMDA receptor hypofunction model of schizophrenia.
J Psychiatr Res 1999, 33: 523-533
SE
Antonarakis, JL Blouin, AE Pulver, P Wolyniec, VK Lasseter, G Nestadt, L Kasch,
R Babb, HH Kazazian, B Dombroski, et al: Schizophrenia susceptibility and
chromosome 6p24-22.
Nat Genet 1995, 11: 235-236
V Arolt, R
Lencer, A Nolte, B Müller-Myhsok, S Purmann, M Schurmann, J Leutelt, M Pinnow, E
Schwinger: Eye tracking dysfunction is a putative phenotypic susceptibility
marker of schizophrenia and maps to a locus on chromosome 6p in families with
multiple occurrence of the disease.
Am J Med Genet 1996, 67: 564-579
U Bailer, F
Leisch, K Meszaros, E Lenzinger, U Willinger, R Strobl, C Gebhardt, E Gerhard, K
Fuchs, W Sieghart, et al: Genome scan for susceptibility loci for schizophrenia.
Neuropsychobiology 2000, 42: 175-182
CL Barr, JL
Kennedy, AJ Pakstis, L Wetterberg, B Sjögren, L Bierut, C Wadelius, J Wahlstrom,
T Martinsson, et al: Progress in a genome scan for linkage in schizophrenia in a
large Swedish kindred.
Am J Med Genet 1994, 54: 51-58
JL Blouin,
BA Dombroski, SK Nath, VK Lasseter, PS Wolyniec, G Nestadt, M Thornquist, G
Ullrich, J McGrath, L Kasch, et al: Schizophrenia susceptibility loci on
chromosomes 13q32 and 8p21.
Nat Genet 1998, 20: 70-73
LM
Brzustowicz, KA Hodgkinson, EW Chow, WG Honer, AS Bassett: Location of a major
susceptibility locus for familial schizophrenia on chromosome 1q21-q22.
Science 2000, 288: 678-82
Q Cao, M
Martinez, J Zhang, AR Sanders, JA Badner, A Cravchik, CJ Markey, E Beshah, JJ
Guroff, et al: Suggestive evidence for a schizophrenia susceptibility locus on
chromosome 6q and a confirmation in an independent series of pedigrees.
Genomics 1997, 43: 1-8
J Collinge,
LE Delisi, A Boccio, EC Johnstone, A Lane, C Larkin, M Leach, R Lofthouse, F
Owen, et al: Evidence for a pseudo-autosomal locus for schizophrenia using the
method of affected sibling pairs.
Br J Psychiatry 1991, 158: 624-629
H Coon, S
Jensen, J Holik, M Hoff, M Myles-Worsley, F Reimherr, P Wender, M Waldo, R
Freedman, M Leppert, et al: Genomic scan for genes predisposing to
schizophrenia.
Am J Med Genet 1994, 54: 59-71
H Coon, M
Myles-Worsley, J Tiobech, M Hoff, J Rosenthal, P Bennett, F Reimherr, P Wender,
P Dale, A Polloi, W Byerley: Evidence for a chromosome 2p13-14 schizophrenia
susceptibility locus in families from Palau, Micronesia.
Mol Psychiatry 1998, 3: 521-527
TJ Crow, LE
Delisi, R Lofthouse, M Poulter, T Lehner, N Bass, T Shah, C Walsh, A Boccio-Smith,
G Shields, et al: An examination of linkage of schizophrenia and schizoaffective
disorder to the pseudoautosomal region (Xp22.3).
Br J Psychiatry 1994, 164: 159-164
J Dann, LE
DeLisi, M Devoto, S Laval, DJ Nancarrow, G Shields, A Smith, J Loftus, P
Peterson, A Vita, et al: A linkage study of schizophrenia to markers within Xp11
near the MAOB gene.
Psychiatry Res 1997, 70: 131-143
LE DeLisi, M
Devoto, R Lofthouse, M Poulter, A Smith, G Shields, N Bass, G Chen, A Vita, C
Morganti, et al: Search for linkage to schizophrenia on the X and Y chromosomes.
Am J Med Genet 1994, 54: 113-121
LE DeLisi,
SH Shaw, TJ Crow, G Shields, AB Smith, VW Larach, N Wellman, J Loftus, B
Nanthakumar, K Razi, et al: A genome-wide scan for linkage to chromosomal
regions in 382 sibling pairs with schizophrenia or schizoaffective disorder.
Am J Psychiatry 2002, 159: 803-812
J Ekelund, D
Lichtermann, I Hovatta, P Ellonen, J Suvisaari, JD Terwilliger, H Juvonen, T
Varilo, R Arajarvi, ML Kokko-Sahin, J Lonnqvist, L Peltonen: Genome-wide scan
for schizophrenia in the Finnish population: evidence for a locus on chromosome
7q22.
Hum Mol Genet 2000, 9: 1049-1057
SV Faraone,
T Matise, D Svrakic, J Pepple, D Malaspina, B Suarez, C Hampe, CT Zambuto, K
Schmitt, J Meyer, et al: Genome scan of European-American schizophrenia
pedigrees: results of the NIMH Genetics Initiative and Millennium Consortium.
Am J Med Genet 1998, 81: 290-295
DL Garver, J
Holcomb, FM Mapua, R Wilson, B Barnes: Schizophrenia spectrum disorders: an
autosomal-wide scan in multiplex pedigrees.
Schizophr Res 2001, 52: 145-160
M Gill, H
Vallada, D Collier, P Sham, P Holmans, R Murray, P McGuffin, S Nanko, M Owen, S
Antonarakis, et al: A combined analysis of D22S278 marker alleles in affected
sib-pairs: support for a susceptibility locus for schizophrenia at chromosome
22q12. Schizophrenia Collaborative Linkage Group (Chromosome 22).
Am J Med Genet 1996, 67: 40-45
HM Gurling,
G Kalsi, J Brynjolfson, T Sigmundsson, R Sherrington, BS Mankoo, T Read, P
Murphy, E Blaveri, A McQuillin, et al: Genomewide genetic linkage analysis
confirms the presence of susceptibility loci for schizophrenia, on chromosomes
1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia,
on chromosomes 11q23.3-24 and 20q12.1-11.23.
Am J Hum Genet 2001, 68: 661-673
I Hovatta, T
Varilo, J Suvisaari, JD Terwilliger, V Ollikainen, R Arajarvi, H Juvonen, ML
Kokko-Sahin, L Vaisanen, H Mannila, J Lonnqvist, L Peltonen: A genomewide screen
for schizophrenia genes in an isolated Finnish subpopulation, suggesting
multiple susceptibility loci.
Am J Hum Genet 1999, 65: 1114-1124
CA Kaufmann,
B Suarez, D Malaspina, J Pepple, D Svrakic, PD Markel, J Meyer, CT Zambuto, K
Schmitt, TC Matise, et al: NIMH Genetics Initiative Millenium Schizophrenia
Consortium: linkage analysis of African-American pedigrees.
Am J Med Genet 1998, 81: 282-289
KS Kendler,
CJ MacLean, FA O'Neill, J Burke, B Murphy, F Duke, R Shinkwin, SM Easter, BT
Webb, J Zhang, et al: Evidence for a schizophrenia vulnerability locus on
chromosome 8p in the Irish Study of High-Density Schizophrenia Families.
Am J Psychiatry 1996, 153: 1534-1540
VK Lasseter,
AE Pulver, PS Wolyniec, G Nestadt, D Meyers, M Karayiorgou, D Housman, S
Antonarakis, H Kazazian, et al: Follow-up report of potential linkage for
schizophrenia on chromosome 22q: Part 3.
Am J Med Genet 1995, 60: 172-173
DF Levinson,
MM Mahtani, DJ Nancarrow, DM Brown, L Kruglyak, A Kirby, NK Hayward, RR Crowe,
NC Andreasen, DW Black, et al: Genome scan of schizophrenia.
Am J Psychiatry 1998, 155: 741-750
DF Levinson,
P Holmans, RE Straub, MJ Owen, DB Wildenauer, PV Gejman, AE Pulver, C Laurent,
KS Kendler, D Walsh, et al: Multicenter linkage study of schizophrenia candidate
regions on chromosomes 5q, 6q, 10p, and 13q: schizophrenia linkage collaborative
group III.
Am J Hum Genet 2000, 67: 652-663
MW Lin, D
Curtis, N Williams, M Arranz, S Nanko, D Collier, P McGuffin, R Murray, M Owen,
M Gill, et al: Suggestive evidence for linkage of schizophrenia to markers on
chromosome 13q14.1-q32.
Psychiatr Genet 1995, 5: 117-126
MW Lin, P
Sham, HG Hwu, D Collier, R Murray, JF Powell: Suggestive evidence for linkage of
schizophrenia to markers on chromosome 13 in Caucasian but not Oriental
populations.
Hum Genet 1997, 99: 417-420
E Lindholm,
B Ekholm, J Balciuniene, G Johansson, A Castensson, M Koisti, PO Nylander, U
Pettersson, R Adolfsson, E Jazin: Linkage analysis of a large Swedish kindred
provides further support for a susceptibility locus for schizophrenia on
chromosome 6p23.
Am J Med Genet 1999, 88: 369-377
M Maziade, V
Raymond, D Cliche, JP Fournier, C Caron, Y Garneau, L Nicole, P Marcotte, C
Couture, C Simard, et al: Linkage results on 11q21-22 in Eastern Quebec
pedigrees densely affected by schizophrenia.
Am J Med Genet 1995, 60: 522-528
M Maziade, L
Bissonnette, E Rouillard, M Martinez, M Turgeon, L Charron, V Pouliot, P Boutin,
D Cliche, C Dion, et al: 6p24-22 region and major psychoses in the Eastern
Quebec population. Le Groupe IREP.
Am J Med Genet 1997, 74: 311-318
HW Moises, L
Yang, H Kristbjarnarson, C Wiese, W Byerley, F Macciardi, V Arolt, D Blackwood,
X Liu, B Sjögren, et al: An international two-stage genome-wide search for
schizophrenia susceptibility genes.
Nat Genet 1995, 11: 321-324
S Nanko, M
Gill, M Owen, N Takazawa, J Moridaira, H Kazamatsuri: Linkage study of
schizophrenia with markers on chromosome 11 in two Japanese pedigrees.
Jpn J Psychiatry Neurol 1992, 46: 155-159
T Paunio, J
Ekelund, T Varilo, A Parker, I Hovatta, JA Turunen, K Rinard, A Foti, JD
Terwilliger, et al: Genome-wide scan in a nationwide study sample of
schizophrenia families in Finland reveals susceptibility loci on chromosomes 2q
and 5q.
Hum Mol Genet 2001, 10: 3037-3048
AE Pulver, M
Karayiorgou, VK Lasseter, P Wolyniec, L Kasch, S Antonarakis, D Housman, HH
Kazazian, D Meyers, G Nestadt, et al: Follow-up of a report of a potential
linkage for schizophrenia on chromosome 22q12-q13.1: Part 2.
Am J Med Genet 1994, 54: 44-50
AE Pulver,
VK Lasseter, L Kasch, P Wolyniec, G Nestadt, JL Blouin, M Kimberland, R Babb, S
Vourlis, H Chen, et al: Schizophrenia: a genome scan targets chromosomes 3p and
8p as potential sites of susceptibility genes.
Am J Med Genet 1995, 60: 252-260
AE Pulver, J
Mulle, G Nestadt, KL Swartz, JL Blouin, B Dombroski, KY Liang, DE Housman, HH
Kazazian, SE Antonarakis, et al: Genetic heterogeneity in schizophrenia:
stratification of genome scan data using co-segregating related phenotypes.
Mol Psychiatry 2000, 5: 650-653
MI Rees, I
Fenton, NM Williams, P Holmans, N Norton, A Cardno, P Asherson, G Spurlock, E
Roberts, E Parfitt, et al: Autosome search for schizophrenia susceptibility
genes in multiply affected families.
Mol Psychiatry 1999, 4: 353-359
BP Riley, A
Makoff, M Mogudi-Carter, T Jenkins, R Williamson, D Collier, R Murray: Haplotype
transmission disequilibrium and evidence for linkage of the CHRNA7 gene region
to schizophrenia in Southern African Bantu families.
Am J Med Genet 2000, 96: 196-201
8 SCLG 6
AND: Additional support for schizophrenia linkage on chromosomes 6 and 8: a
multicenter study. Schizophrenia Linkage Collaborative Group for Chromosomes 3,
6 and 8.
Am J Med Genet 1996, 67: 580-594
SG Schwab, M
Albus, J Hallmayer, S Honig, M Borrmann, D Lichtermann, RP Ebstein, M Ackenheil,
B Lerer, N Risch, et al: Evaluation of a susceptibility gene for schizophrenia
on chromosome 6p by multipoint affected sib-pair linkage analysis.
Nat Genet 1995, 11: 325-327
SG Schwab, B
Lerer, M Albus, W Maier, J Hallmayer, R Fimmers, D Lichtermann, J Minges, B
Bondy, M Ackenheil, et al: Potential linkage for schizophrenia on chromosome
22q12-q13: a replication study.
Am J Med Genet 1995, 60: 436-443
SG Schwab,
GN Eckstein, J Hallmayer, B Lerer, M Albus, M Borrmann, D Lichtermann, MA Ertl,
W Maier, DB Wildenauer: Evidence suggestive of a locus on chromosome 5q31
contributing to susceptibility for schizophrenia in German and Israeli families
by multipoint affected sib-pair linkage analysis.
Mol Psychiatry 1997, 2: 156-160
SG Schwab, J
Hallmayer, M Albus, B Lerer, C Hanses, K Kanyas, R Segman, M Borrman, B Dreikorn,
D Lichtermann, et al: Further evidence for a susceptibility locus on chromosome
10p14-p11 in 72 families with schizophrenia by nonparametric linkage analysis.
Am J Med Genet 1998, 81: 302-307
SG Schwab, J
Hallmayer, B Lerer, M Albus, M Borrmann, S Honig, M Strauss, R Segman, D
Lichtermann, M Knapp, et al: Support for a chromosome 18p locus conferring
susceptibility to functional psychoses in families with schizophrenia, by
association and linkage analysis.
Am J Hum Genet 1998, 63: 1139-1152
SG Schwab, J
Hallmayer, M Albus, B Lerer, GN Eckstein, M Borrmann, RH Segman, C Hanses, J
Freymann, A Yakir, et al: A genome-wide autosomal screen for schizophrenia
susceptibility loci in 71 families with affected siblings: support for loci on
chromosome 10p and 6.
Mol Psychiatry 2000, 5: 638-649
SH Shaw, M
Kelly, AB Smith, G Shields, PJ Hopkins, J Loftus, SH Laval, A Vita, M De Hert,
LR Cardon, et al: A genome-wide search for schizophrenia susceptibility genes.
Am J Med Genet 1998, 81: 364-376
R
Sherrington, J Brynjolfsson, H Petursson, M Potter, K Dudleston, B Barraclough,
J Wasmuth, M Dobbs, H Gurling: Localization of a susceptibility locus for
schizophrenia on chromosome 5.
Nature 1988, 336: 164-167
JM
Silverman, DA Greenberg, LD Altstiel, LJ Siever, RC Mohs, CJ Smith, G Zhou, TE
Hollander, XP Yang, M Kedache, et al: Evidence of a locus for schizophrenia and
related disorders on the short arm of chromosome 5 in a large pedigree.
Am J Med Genet 1996, 67: 162-171
D St Clair,
D Blackwood, W Muir, A Carothers, M Walker, G Spowart, C Gosden, HJ Evans:
Association within a family of a balanced autosomal translocation with major
mental illness.
Lancet 1990, 336: 13-16
G Stöber, K
Saar, F Ruschendorf, J Meyer, G Nurnberg, S Jatzke, E Franzek, A Reis, KP Lesch,
TF Wienker, H Beckmann: Splitting schizophrenia: periodic
catatonia-susceptibility locus on chromosome 15q15.
Am J Hum Genet 2000, 67: 1201-1207
RE Straub,
CJ MacLean, FA O'Neill, J Burke, B Murphy, F Duke, R Shinkwin, BT Webb, J Zhang,
D Walsh, et al: A potential vulnerability locus for schizophrenia on chromosome
6p24-22: evidence for genetic heterogeneity.
Nat Genet 1995, 11: 287-293
RE Straub,
CJ MacLean, FA O'Neill, D Walsh, KS Kendler: Support for a possible
schizophrenia vulnerability locus in region 5q22-31 in Irish families.
Mol Psychiatry 1997, 2: 148-155
RE Straub,
CJ MacLean, RB Martin, Y Ma, MV Myakishev, C Harris-Kerr, BT Webb, FA O'Neill, D
Walsh, KS Kendler: A schizophrenia locus may be located in region 10p15-p11.
Am J Med Genet 1998, 81: 296-301
WJ Turner:
Genetic markers for schizotaxia.
Biol Psychiatry 1979, 14: 177-206
HP Vallada,
M Gill, P Sham, LC Lim, S Nanko, P Asherson, RM Murray, P McGuffin, M Owen, D
Collier: Linkage studies on chromosome 22 in familial schizophrenia.
Am J Med Genet 1995, 60: 139-146
S Wang, CE
Sun, CA Walczak, JS Ziegle, BR Kipps, LR Goldin, SR Diehl: Evidence for a
susceptibility locus for schizophrenia on chromosome 6pter-p22.
Nat Genet 1995, 10: 41-46
DB
Wildenauer, J Hallmayer, SG Schwab, M Albus, GN Eckstein, P Zill, S Honig, M
Strauss, M Borrmann, D Lichtermann, et al: Searching for susceptibility genes in
schizophrenia by genetic linkage analysis.
Cold Spring Harb Symp Quant Biol 1996, 61: 845-850
NM Williams,
MI Rees, P Holmans, N Norton, AG Cardno, LA Jones, KC Murphy, RD Sanders, G
McCarthy, MY Gray, et al: A two-stage genome scan for schizophrenia
susceptibility genes in 196 affected sibling pairs.
Hum Mol Genet 1999, 8: 1729-1739
E Lander, L
Kruglyak: Genetic dissection of complex traits: guidelines for interpreting and
reporting linkage results.
Nat Genet 1995, 11: 241-247
V
Chalifa-Caspi, J Prilusky, D Lancet:
The Unified Database. Rehovot, Israel: Weizmann Institute of Science,
Bioinformatics Unit and Genome Center; 1998
II
Gottesman, J Shields: A polygenic theory of schizophrenia.
Proc Natl Acad Sci USA 1967, 58:
199-205
JM Tanner:
Human growth and development.
In: The Cambridge Encyclopedia of Human Evolution (Edited by: Jones S, Martin,
R, Pilbeam, D). Cambridge, Cambridge University Press 1992, 98-105
HT Chugani,
ME Phelps, JC Mazziotta: Positron emission tomography study of human brain
functional development.
Ann Neurol 1987, 22: 487-497
MR Cohen, E
Nagel:
An introduction to logic and scientific method. New York: Hartcourt; 1934
Chieri, P.R.: Transmisión hereditaria. En Genética Clínica, diagnóstico y prevención de las enfermedades genéticas. Cap. 1 p: 7-30. Editado por Libreros López. Buenos Aires. Argentina. 1998.
Emery, A.E.H.: Elements of Medical Genetics. In the development of Genetics. p.p. 1. Edited by Churchill Livinstone. Edinburo and London, 1974.
Klinger, H.P.: Personal comunication to Steele and Breg, 1966.
Nadler, H.L.: Antenatal detection of hereditary disorders. Pediatrics 42: 912, 1968.
Steele, M.V.; Breg, W.R.: Chromosome analysis of human amniotic fluid cells. Lancet, 1: 383. 1966.
Watson, J.D.; Crick, F.H.: Genetic implications of the structure of deosyribonucleic acid. Nature, (Lond) 171: 964, 1953.
Weatherall, D.J.: The new genetics and clinical practice. Edited by Oxford University Press, 1985.
Atkins, C.M.; Selcher, J.C.; Petraitis J.J.; Trzaskos, L.M.; Sweatt, J.D.: The mapk cascade is required for mammalian associative learning. Nature America Inc. November 1998, vol. 1. n° 7, pp 602-609.
Impey, S.; Smith, D.M.; Obrietan, K.; Donahue, R.; Wade, C.; Storm, D.R.: Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning. Nature America Inc. November 1998. vol. 1, n° 7, pp 595-601.
Galarreta, M.; Hestrin, S.: Frecuency-dependent synaptic depression and the balance of excitation and inhibition in the neocortex. Nature America Inc. November 1998, vol. 1, n° 7, pp 587-594.
Mainen, Z.F.; Jia, Z.; Roder, J.; Malinow, R.: Use-dependent AMPA receptor block in mice lacking GluR2 suggests postsynaptic site for LTP expression. Nature America Inc. November 1998. vol. 1, n° 7, pp 579-586.
Tóth, K.; McBain, J.: Afferent-specific innervation of two distinct AMPA receptor subtypes on single hippocampal interneurons. Nature America Inc. November 1998. vol. 1, n° 7, pp 572-578.
Essrich, C.; Lorez, M.; Benson, J.; Fritschy, J.M.; Luscher, B.: Postsynaptic clustering of major Gaba A receptor subtypes requires the gamma 2 subunit and gephyrin. Nature America Inc. November 1998. vol 1, n° 7, pp 563-571.
Williams, B.M.; Temburini, M.K.; Levey, M.S.; Bertrand, S.; Bertrand, D.; Jacob, M.H.: The long internal loop of the 3 subunit targets nAChRs to subdomains within individual synapses on neurons in vivo. Nature America Inc. November 1998. vol 1, n°7, pp 557-562.
Salem, N.; Faúndez, V.; Horng, J.T.; Kelly, R.B.:A v-snare participates in synaptic vesicle formation mediated by the ap3 adaptor complex. Nature America Inc. November 1998. vol 1, n° 7, pp 551-556.
Heun, R.; Maire, W.; Muller, H.: Subject and informant variables affecting family history diagnoses of depression and dementia. Psychiatry Res. 1997, Aug. 8; 71(3): 175-180.
Teri, L.; Logsdon, R.G.; Uomoto, J.; McCurry, S.M.: Behavioral treatment of depression in dementia patients: a controlled clinical trial. J. Gerontol. B. Psychol. Sci. Soc. Sci. 1997. Jul; 52(4): p159-166.
Lundquist,R.S.; Bernens, A.; Olsen, C.G.: Comorbid disease in geriatric patients: dementia and depression. Am. Fam. Physician 1997. Jun; 55(8): p 2687-2694.
Burke, W.J.; Dewan, V.; Wengel, S.P.; Roccaforte, W.H.; Nadolny, G.C.; Folks, D.G.: The use of selective serotonin reuptake inhibitors for depression and psychosis complicating dementia. Int. J. Geriatr. Psychiatry 1997. May; 12(5): p 519-525.
Small GW, Rabins PV, Barry PP, Buckholtz NS, DeKosky ST, Ferris SH, et al. Diagnosis and treatment of Alzheimer disease and related disorders. Consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer's Association, and the American Geriatrics Society. JAMA 1997;278:1363-71.
Agency for Health Care Policy and Research. Recognition and initial assessment of Alzheimer's disease and related dementias. Clinical practice guideline no. 19.
Rockville, Md.: Dept. of Health and Human Services, Public Health Services, 1996; AHCPR publication no. 97-0702.
Whitehouse PJ. Genesis of Alzheimer's disease. Neurology 1997;48(5 Suppl 7):S2-7.
Selkoe DJ. Alzheimer's disease: genotypes, phenotypes, and treatments. Science 1997;275:630-1.
Apolipoprotein E genotyping in Alzheimer's disease. Lancet 1996;347:1091-5.
Folstein MF, Folstein SE, McHugh PR. "Mini-mental state." A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-98.
Filley CM. Alzheimer's disease: it's irreversible but not untreatable. Geriatrics 1995;50:18-23.
Cummings JL, Cyrus PA, Bieber F, Mas J, Orazem J, Gulanski B. Metrifonate treatment of the cognitive deficits of Alzheimer's disease. Neurology 1998;50: 1214-21.
Lovestone S, Graham N, Howard R. Guidelines on drug treatments for Alzheimer's disease. Lancet 1997;350:232-3.
Tang MX, Jacobs D, Stern Y, Marder K, Schofield P, Gurland B, et al. Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet 1996;348:429-32.
Paganini-Hill A, Henderson VW. Estrogen replacement therapy and risk of Alzheimer's disease. Arch Intern Med 1996;156:2213-7.
Kawas C, Resnick S, Morrison A, Brookmeyer R, Corrada M, Zonderman A, et al. A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: the Baltimore Longitudinal Study on Aging. Neurology 1997;48:1517-21.
Stewart WF, Kawas C, Corrada M, Metter EJ. Risk of Alzheimer's disease and duration of NSAID use. Neurology 1997;48:626-32.
Rozzini R, Ferrucci L, Losonczy K, Havlik RJ, Guralnik JM. Protective effect of chronic NSAID use on cognitive decline in older persons. J Am Geriatr Soc 1996;44:1025-9.
Practice guideline for the treatment of patients with Alzheimer's disease and other dementias of late life. Am J Psychiatry 1997;154(5 Suppl):1-39 [Published erratum appears in Am J Psychiatry 1997;154:1180].
Sano M, Ernesto C, Thomas RG, Klauber MR, Schafer K, Grundman M, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med 1997;336:1216-22.
Le Bars PL, Katz MM, Berman N, Itil TM, Freedman AM, Schatzberg AF, et al. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. JAMA 1997;278:1327-32.
Burns A, Murphy D. Protection against Alzheimer's disease? Lancet 1996;348:420-1.
Mor V, Banaszak-Holl J, Zinn J. The trend toward specialization in nursing care facilities. Generations 1996;19:24-9.
Phillips CD, Sloane PD, Hawes C, Koch G, Han J, Spry K, et al. Effects of residence in Alzheimer disease special care units on functional outcomes. JAMA 1997;278:1340-4 [Published erratum appears in JAMA 1998;279:1376-7].
Ferrell BA, Ferrell BR, Rivera L. Pain in cognitively impaired nursing home patients. J Pain Symptom Manage 1995;10:591-8.
Mitchell SL, Kiely DK, Lipsitz LA. The risk factors and impact on survival of feeding tube placement in nursing home residents with severe cognitive impairment. Arch Intern Med 1997;157:327-32.
Hall GR. Examining the end stage: what can we do when we can't do any more? [Editorial] J Gerontol Nurs 1991;17:3-4.
McCann RM, Hall WJ, Groth-Juncker A. Comfort care for terminally ill patients. The appropriate use of nutrition and hydration. JAMA 1994;272:1263-6.
Alzheimer's Association. Care for advanced Alzheimer's disease. Chicago: Alzheimer's Association, 1994.
Besdine RW, Jarvik LF, Tangalos EG. Managing advanced Alzheimer's disease. Patient Care 1991; 25:75-100.
Tellez Vargas J., López Mato A.; Aspectos neurocognitivos de la esquizofrenia. Nuevo milenio editores. Bogotá 2001. Aspectos genéticos; 2: p15-31.
Asherson P., Mant R., McGuffin D.; Genetics and Schizophrenia. En: Schizophrenia., Hirsh S, Weinberger D (eds), Inglaterra 1995.
Blouin J., Dombroski B.S.; Schizophrenia susceptibility loci identified on chromosomes 13q32 and 8p21. Nature Genetics. Septiembre 1998.
Cook E. Genetic of psychiatric disorders: Where have we been and where are we going?. Am. Journal of Psychiatry, Washington; 2000; 157(7): 1039-1040.
Delisi L.,The Genetics of Schizophrenia: Past, Present and Future Concepts. SCRSEH 28 (1997) 163-175.
Terry RD, Masliah E, Hansen LA. Structural basis of the cognitive alterations in Alzheimer disease. In: Terry RD, Katzman R, Bick KL, editors. Alzheimer disease. New York: Raven Press; 1994. p. 179-96.
Etienne P, Robitaille Y, Wood P, Gauthier S, Nair NPV, Quirion R. Nucleus basalis neuronal loss, neuritic plaques and choline acetyltransferase activity in advanced Alzheimer's disease. Neuroscience 1986;19:1279-91.
Poirier J: Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease. Trends Neurosci 1994;17:525-30.
Poirier J, Baccichet A, Dea D, Gauthier S. Role of hippocampal cholesterol synthesis and uptake during reactive synaptogenesis in adult rats. Neuroscience 1993;55:81-90.
Poirier J, Davignon J, Bouthillier D, Kogan S, Bertrand P, Gauthier S.
Apolipoprotein E phenotype and Alzheimer's disease. Lancet 1993;342:697-9.
Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, et al. Gene dose of apolipoprotein E type 4 and risk of Alzheimer's disease in late onset families. Science 1993;261:921-3.
Hardy J. The Alzheimer family of diseases: Many etiologies, one pathogenesis? Proc Natl Acad Sci USA 1997;94:2095-7.
Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, et al. Alzheimer-like neuropathology in transgenic mice over expressing V717F beta-amyloid precursor protein. Nature 1995;373:523-7.
Hsiao K, Chapman P, Nilsen S, Eckman V, Harigaya Y, Younkin S, et al. Correlative memory deficits, A-beta elevation and amyloid plaques in transgenic mice. Science 1996;274:99-102.
Nalbantoglu J, Tirado-Santiago G, Lahsaini A, Poirier J, Goncalves O, Verge A, et al. Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein. Nature 1997;387:500-5.
Blass, JP, Poirier J: Pathophysiology of the Alzheimer syndrome. In: Gauthier S, editor. Clinical diagnosis and management of Alzheimer's disease. London (UK): Martin Dunitz Publishers; 1996. p. 17-27.
Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA 1997;277:813-7.
Canadian Study of Health and Aging Working Group: Canadian Study of Health and Aging: study methods and prevalence of dementia. CMAJ 1994;150:899-913.
Ebly EM, Parhad IM, Hogan DB, Fung TS. Prevalence and types of dementia in the very old: results from the Canadian Study of Health and Aging. Neurology 1994;44:1593-600.
Graham JE, Rockwood K, Beattie BL, McDowell I, Eastwood R, Gauthier S. Prevalence and severity of cognitive impairment with and without dementia in an elderly population. Lancet 1997;349:1793-6.
Canadian Study of Health and Aging. The Canadian Study of Health and Aging: risk factors for Alzheimer's disease in Canada. Neurology 1994;44:2073-80.
Canadian Study of Health and Aging. Patterns of caring for people with dementia in Canada. Can J Aging 1994;13:470-87.
Katzman R, Kawas C. The epidemiology of dementia and Alzheimer's disease. In: Terry RD, Katzman R, Bick KL, editors. Alzheimer's disease. New York: Raven Press; 1994. p. 105-22.
Kokmen E, Beard CM, O'Brien PC, Offord KP, Kurland LT. Is the incidence of dementing illness changing? A 25-year time trend study in Rochester, Minnesota (19601984). Neurology 1993;43:1887-92.
American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington: The Association; 1994.