Referencias Bibliográficas sobre Psiquiatría Biológica:

  

A Sawa, SH Snyder: Schizophrenia: diverse approaches to a complex disease.
Science 2002, 296: 692-695

             

IIGottesman: Schizophrenia Genesis: The Origins of Madness. New York: W.H. Freeman; 1991

             

HW Moises, II Gottesman: Genetics, risk and personality factors.
In: Contemporary Psychiatry (Edited by: Henn F, Sartorius, H, Helmchen H, Lauter, N). Heidelberg, New York: Springer 2000, 3: 47-59

             

II Gottesman: Psychopathology through a life span – genetic prism.

Am Psychologist 2001, 56: 867-878

             

RM Murray, SW Lewis: Is schizophrenia a neurodevelopmental disorder?
Br Med J 1987, 295: 681-682

             

S Marenco, DR Weinberger: The neurodevelopmental hypothesis of schizophrenia: following a trail of evidence from cradle to grave.
Dev Psychopathol 2000, 12: 501-527

             

HWM Moises: Human Genome data analyzed by an evolutionary method suggests a decrease in protein-synthesis rate as cause of schizophrenia and an increase as antipsychotic mechanism.
ArXiv.org e-Print archive 2001

             

DA Lewis, P Levitt: Schizophrenia as a disorder of neurodevelopment.
Annu Rev Neurosci 2002, 25: 409-432

           

CS Monk, SJ Webb, CA Nelson: Prenatal neurobiological development: molecular mechanisms and anatomical change.
Dev Neuropsychol 2001, 19: 211-236

                         

SJ Webb, CS Monk, CA Nelson: Mechanisms of postnatal neurobiological development: implications for human development.
Dev Neuropsychol 2001, 19: 147-171        

             

G Lemke: Glial control of neuronal development.
Annu Rev Neurosci 2001, 24: 87-105

 

DR Cotter, CM Pariante, IP Everall: Glial abnormalities in major psychiatric disorders: the evidence and implications.
Brain Res Bull 2001, 55: 585-595

           

Y Hakak, JR Walker, C Li, WH Wong, KL Davis, JD Buxbaum, V Haroutunian, AA Fienberg: Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia.
Proc Natl Acad Sci U S A 2001, 98: 4746-4751

 

M Rothermundt, U Missler, V Arolt, M Peters, J Leadbeater, M Wiesmann, S Rudolf, KP Wandinger, H Kirchner: Increased S100B blood levels in unmedicated and treated schizophrenic patients are correlated with negative symptomatology.
Mol Psychiatry 2001, 6: 445-449

           

DR Lara, CS Gama, P-de-Abreu Belmonte, LV Portela, CA Goncalves, M Fonseca, S Hauck, DO Souza: Increased serum S100B protein in schizophrenia: a study in medication-free patients.
J Psychiatr Res 2001, 35: 11-14

           

NM Williams, MC O'Donovan, MJ Owen: Genome scans and microarrays: converging on genes for schizophrenia?
Genome Biology 2002 2002, 3: 1-1011

           

AB Goodman: Three independent lines of evidence suggest retinoids as causal to schizophrenia.
Proc Natl Acad Sci U S A 1998, 95: 7240-7244

           

ABr Niculescu, JR Kelsoe: Convergent functional genomics: application to bipolar disorder.
Ann Med 2001, 33: 263-271

           

K Mirnics, FA Middleton, GD Stanwood, DA Lewis, P Levitt: Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia.
Mol Psychiatry 2001, 6: 293-301

           

S Burden, Y Yarden: Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis.
Neuron 1997, 18: 847-855

 

A Buonanno, GD Fischbach: Neuregulin and ErbB receptor signaling pathways in the nervous system.
Curr Opin Neurobiol 2001, 11: 287-296

           

             

H Song, CF Stevens, FH Gage: Astroglia induce neurogenesis from adult neural stem cells.
Nature 2002, 417: 425

           

             

PG Haydon: GLIA: listening and talking to the synapse.
Nat Rev Neurosci 2001, 2: 185-193

           

             

A Araque, V Parpura, RP Sanzgiri, PG Haydon: Tripartite synapses: glia, the unacknowledged partner.
Trends Neurosci 1999, 22: 208-215

           

 

SJ Morley: Signal transduction mechanisms in the regulation of protein synthesis.
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O Steward, EM Schuman: Protein synthesis at synaptic sites on dendrites.
Annu Rev Neurosci 2001, 24: 299-325

 

             

EM Schuman: Neurotrophin regulation of synaptic transmission.
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L Fromm, SJ Burden: Neuregulin-1-stimulated phosphorylation of GABP in skeletal muscle cells.
Biochemistry 2001, 40: 5306-5312

           

             

P Bezzi, A Volterra: A neuron-glia signalling network in the active brain.
Curr Opin Neurobiol 2001, 11: 387-394

           

             

YZ Huang, S Won, DW Ali, Q Wang, M Tanowitz, QS Du, KA Pelkey, DJ Yang, WC Xiong, MW Salter, L Mei: Regulation of neuregulin signaling by PSD-95 interacting with erbB4 and CNS synapses.
Neuron 2000, 26: 443-455

           

             

ES Anton, MA Marchionni, KF Lee, P Rakic: Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex.
Development 1997, 124: 3501-3510

           

             

V Calaora, B Rogister, K Bismuth, K Murray, H Brandt, P Leprince, M Marchionni, M Dubois-Dalcq: Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro.
J Neurosci 2001, 21: 4740-4751

           

             

D Wolpowitz, TB Mason, P Dietrich, M Mendelsohn, DA Talmage, LW Role: Cysteine-rich domaine isoforms of the neuregulin-1 gene are required for maintenance of periphereal synapses.
Neuron 2000, 25: 79-91 

           

             

JA Loeb, A Hmadcha, GD Fischbach, SJ Land, VL Zakarian: Neuregulin expression at neuromuscular synapses is modulated by synaptic activity and neurotrophic factors.
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K Adlkofer, C Lai: Role of neuregulins in glial cell development.
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JY Wang, KE Frenzel, D Wen, DL Falls: Transmembrane neuregulins interact with LIM kinase 1, a cytoplasmic protein kinase implicated in development of visuospatial cognition.
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MA Olayioye, RM Neve, HA Lane, NE Hynes: The ErbB signaling network: receptor heterodimerization in development and cancer.
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Y Liu, B Ford, MA Mann, GD Fischbach: Neuregulins increase alpha7 nicotinic acetylcholine receptors and enhance excitatory synaptic transmission in GABAergic interneurons of the hippocampus.
J Neuroci 2001, 21: 5660-5669

                         

MK Sapru, SK Florance, C Kirk, D Goldman: Identification of a neuregulin and protein-tyrosine phosphatase response element in the nicotinic acetylcholine receptor E subunit gene: Regulatory role of an Ets transcription factor.
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DE Syroid, TS Zorick, C Arbet-Engels, TJ Kilpatrick, W Eckhart, G Lemke: A role for insulin-like growth factor-I in the regulation of Schwann cell survival.
J Neurosci 1999, 19: 2059-2068

             

CM Hertig, SW Kubalak, Y Wang, KR Chien: Synergistic roles of neuregulin-1 and insulin-like growth factor-I in activation of the phosphatidylinositol 3-kinase pathway and cardiac chamber morphogenesis.
J Biol Chem 1999, 274: 37362-37369

             

C Sweeney, D Fambrough, C Huard, AJ Diamonti, ES Lander, LC Cantley, KL Carraway 3rd: Growth factor-specific signaling pathway stimulation and gene expression mediated by ErbB receptors.
J Biol Chem 2001, 276: 22685-22698

             

LA Scheving, WE Russell: Insulin and heregulin-beta1 upregulate guanylyl cyclase C expression in rat hepatocytes: reversal by phosphodiesterase-3 inhibition.
Cell Signal 2001, 13: 665-672

             

R Li, J Chen, G Hammonds, H Phillips, M Armanini, P Wood, R Bunge, PJ Godowski, MX Sliwkowski, JP Mather: Identification of Gas6 as a growth factor for human Schwann cells.
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MP Allen, C Zeng, K Schneider, X Xiong, MK Meintzer, P Bellosta, C Basilico, B Varnum, KA Heidenreich, ME Wierman: Growth arrest-specific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and Akt.
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S Goruppi, E Ruaro, B Varnum, C Schneider: Requirement of phosphatidylinositol 3-kinase-dependent pathway and Src for Gas6-Axl mitogenic and survival activities in NIH 3T3 fibroblasts.
Mol Cell Biol 1997, 17: 4442-4453

             

R Eilam, R Pinkas-Kramarski, BJ Ratzkin, M Segal, Y. Yarden: Activity-dependent regulation of Neu differentiation factor/neuregulin expression in rat brain.
Proc Natl Acad Sci U S A 1998, 95: 1888-1893

             

GS Naeve, M Ramakrishnan, R Kramer, D Hevroni, Y Citri, LE Theill: Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis.
Proc Natl Acad Sci U S A 1997, 94: 2648-2653

             

P Subramony, SE Dryer: Neuregulins stimulate the functional expression of Ca2+-activated K+ channels in developing chicken parasympathetic neurons.
Proc Natl Acad Sci U S A 1997, 94: 5934-5938

             

JS Cameron, L Dryer, SE Dryer: beta-Neuregulin-1 is required for the in vivo development of functional Ca2+-activated K+ channels in parasympathetic neurons.
Proc Natl Acad Sci U S A 2001, 98: 2832-2836

             

H Thoenen: Neurotrophins and neuronal plasticity.
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M Canossa, O Griesbeck, B Berninger, G Campana, R Kolbeck, H Thoenen: Neurotrophin release by neurotrophins: implications for activity-dependent neuronal plasticity.
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U Otten, P Marz, K Heese, C Hock, D Kunz, S Rose-John: Cytokines and neurotrophins interact in normal and diseased states.
Ann N Y Acad Sci 2000, 917: 322-330

             

M Canossa, A Gartner, G Campana, N Inagaki, H Thoenen: Regulated secretion of neurotrophins by metabotropic glutamate group I (mGluRI) and Trk receptor activation is mediated via phospholipase C signalling pathways.
Embo J 2001, 20: 1640-1650

             

E Alleva, D Santucci: Psychosocial vs. "physical" stress situations in rodents and humans: role of neurotrophins.
Physiol Behav 2001, 73: 313-320

             

RR Baliga, DR Pimental, YY Zhao, WW Simmons, MA Marchionni, DB Sawyer, RA Kelly: NRG-1-induced cardiomyocyte hypertrophy. Role of PI-3-kinase, p70(S6K), and MEK-MAPK-RSK.
Am J Physiol 1999, 277: H2026-2037

             

M Kleijn, GI Welsh, GC Scheper, HO Voorma, CG Proud, AA Thomas: Nerve and epidermal growth factor induce protein synthesis and eIF2B activation in PC12 cells.
J Biol Chem 1998, 273: 5536-5541

             

DG Wells, JD Richter, JR Fallon: Molecular mechanisms for activity-regulated protein synthesis in the synapto-dendritic compartment.
Curr Opin Neurobiol 2000, 10: 132-137

             

ER Kandel, JH Schwartz, TM Jessell:
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M Shelly, R Pinkas-Kramarski, BC Guarino, H Waterman, LM Wang, L Lyass, M Alimandi, A Kuo, SS Bacus, JH Pierce, GC Andrews, Y Yarden: Epiregulin is a potent pan-ErbB ligand that preferentially activates heterodimeric receptor complexes.
J Biol Chem 1998, 273: 10496-10505

             

R Gerlai, N Shinsky, A Shih, P Williams, J Winer, M Armanini, B Cairns, J Winslow, W Gao, HS Phillips: Regulation of learning by EphA receptors: a protein targeting study.
J Neurosci 1999, 19: 9538-9549

             

JC Conover, F Doetsch, JM Garcia-Verdugo, NW Gale, GD Yancopoulos, A Alvarez-Buylla: Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone.
Nat Neurosci 2000, 3: 1091-1097

             

JP Wagner, IB Black, E DiCicco-Bloom: Stimulation of neonatal and adult brain neurogenesis by subcutaneous injection of basic fibroblast growth factor.
J Neurosci 1999, 19: 6006-6016

             

AL Boxer, H Moreno, B Rudy, EB Ziff: FGF-2 potentiates Ca(2+)-dependent inactivation of NMDA receptor currents in hippocampal neurons.
J Neurophysiol 1999, 82: 3367-3377

             

DM Araujo, CW Cotman: Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal cultures: potential involvement of glial-derived factors.
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EC Beattie, D Stellwagen, W Morishita, JC Bresnahan, BK Ha, M Von Zastrow, MS Beattie, RC Malenka: Control of synaptic strength by glial TNFalpha.
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R Hemi, K Paz, N Wertheim, A Karasik, Y Zick, H Kanety: Transactivation of ErbB2 and ErbB3 by tumor necrosis factor-alpha and anisomycin leads to impaired insulin signaling through serine/threonine phosphorylation of IRS proteins.
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A Carrie, L Jun, T Bienvenu, MC Vinet, N McDonell, P Couvert, R Zemni, A Cardona, G Van Buggenhout, S Frints, et al: A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation.
Nat Genet 1999, 23: 25-31

             

JH Pak, FL Huang, J Li, D Balschun, KG Reymann, C Chiang, H Westphal, KP Huang: Involvement of neurogranin in the modulation of calcium/calmodulin-dependent protein kinase II, synaptic plasticity, and spatial learning: a study with knockout mice.
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H Häfner: Onset and early course as determinants of the further course of schizophrenia.
Acta Psychiatr Scand Suppl 2000, 102: 44-48

             

J Klosterkötter, M Hellmich, EM Steinmeyer, F Schultze-Lutter: Diagnosing schizophrenia in the initial prodromal phase.
Arch Gen Psychiatry 2001, 58: 158-164

             

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S Leonard, J Gault, T Moore, J Hopkins, M Robinson, A Olincy, LE Adler, CR Cloninger, CA Kaufmann, et al: Further investigation of a chromosome 15 locus in schizophrenia: analysis of affected sibpairs from the NIMH Genetics Initiative.
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R Freedman, H Coon, M Myles-Worsley, A Orr-Urtreger, A Olincy, A Davis, M Polymeropoulos, J Holik, J Hopkins, M Hoff, et al: Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus.
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J Williams, P McGuffin, M Nöthen, MJ Owen: Meta-analysis of association between the 5-HT2a receptor T102C polymorphism and schizophrenia. EMASS Collaborative Group. European Multicentre Association Study of Schizophrenia.
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N Iwata, N Ozaki, D Goldman: Association of a 5-HT(5A) receptor polymorphism, Pro15Ser, to schizophrenia.
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E Jonsson, S Brene, XR Zhang, VL Nimgaonkar, A Tylec, M Schalling, G Sedvall: Schizophrenia and neurotrophin-alleles.
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RS Devon, S Anderson, PW Teague, WJ Muir, V Murray, A Pelosi, DH Blackwood, DJ Porteous: The genomic organisation of the metabotropic glutamate receptor subtype 5 gene, and its association with schizophrenia.
Mol Psychiatry 2001, 6: 311-314

             

J Wei, GP Hemmings: The NOTCH4 locus is associated with susceptibility to schizophrenia.
Nat Genet 2000, 25: 376-377

             

HW Moises, P Matthiasson, T Zoega, G Jhala, L Yang, II Gottesman, T. Helgason: Neuregulin 1 strongly implicated as susceptibility gene for schizophrenia by allelic association study.
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V Dror, E Shamir, S Ghanshani, R Kimhi, M Swartz, Y Barak, R Weizman, L Avivi, T Litmanovitch, E Fantino, et al: hKCa3/KCNN3 potassium channel gene: association of longer CAG repeats with schizophrenia in Israeli Ashkenazi Jews, expression in human tissues and localization to chromosome 1q21.
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H Liu, SC Heath, C Sobin, JL Roos, BL Galke, ML Blundell, M Lenane, B Robertson, EM Wijsman, JL Rapoport, et al: Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia.
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A Chakravarti: A compelling genetic hypothesis for a complex disease: PRODH2/DGCR6 variation leads to schizophrenia susceptibility.
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